I've noticed having multiple sites open at once is normally not much of a problem. However, when you add Cake into the mix with no HUD, it does become a little more tricky, as I have to make sure I have time to make manual notes. I'm still comfortable with 4 tables open, although it can be a little hectic and occasionally I need to open hand histories to back track on notes on some players.
I don't think it hurts my win rate though, as I can spot the fish relatively quickly, although do have the occasional revision where i've mistaken a LAG for a fish.
I got in about an hour of play last night, which turned out to be relatively profitable. Cake had some nice $2/4 and $3/6 tables, although I didn't really go far with them but made a few BBs. Should have some nice rakeback though. I found a nice $2/4 table on Interpoker though, and for once I didn't get slaughtered there. I'm back to being a bit better than -3BB/100 there now ... after making 25BBs ... sheesh. There was one other pretty decent table on interpoker with two tags and three pretty big fish. Problem was I found myself directly to the left of the two tags, and that made for some pretty hard going, so I quit the table after a couple orbits.
Current bankroll: $14,000